The changes make it last much longer in the body than natural IGF-1, so its growth signal keeps firing for a longer stretch
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Caspases can serve different roles in the apoptotic cascade: some act as initiators (e.g., caspase-8, caspase-9), while others function as effectors (e.g., caspase-3, -6, -7), ultimately executing apoptosis by cleaving essential cellular proteins [159]
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Sustained IGF1R activation across that timeline using native IGF-1 would require multiple daily media changes